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Anti-SUV39H1 Antibody, clone MG44
| 半岛bd体育手机客户端 编号： | 4085226 |
| 规格： | ascites fluid, clone MG44, Upstate? |
| 包装规格： | 200 μL |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
Anti-SUV39H1 Antibody, clone MG44
KMT1A
基本信息
| eCl@ss |
32160702
|
| NACRES |
NA.41
|
| General description【一般描述】 |
Post -translational modification of histones, such as phosphorylation, acetylation, and methylation, are crucial for chromatin remodeling. SUV39H1 and Suv39h1 are the human and mouse homologs of Drosophila Su(var)3-9 protein, respectively. These proteins selectively methylate histone H3 at lysine 9 creating a high-affinity binding site for the HP1 proteins (heterochromatin protein 1). HP1 proteins are known to interact with transcription suppressor proteins, suggesting that the interactions with SUV39H1 and methylated histone H3 mediate a silence effect on the transcription of target genes. Furthermore, over-expression of SUV39H1 in HeLa cells causes a redistribution of endogenous HP1 proteins and growth retardation, suggesting that SUV39H1-mediated modulation of heterochromatin can impair cell cycle progression.
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| Specificity【特异性】 |
Recognizes SUV39H1.
|
| Immunogen【免疫原】 |
MBP fusion protein corresponding to residues 1-412 of human SUV39H1
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| Application【应用】 |
Anti-SUV39H1 Antibody, clone MG44 is a Mouse Monoclonal Antibody for detection of SUV39H1 also known as KMT1A, Histone H3-K9 Methyltransferase 1 & has been validated in ChIP, IP & WB.
Research Category Epigenetics & Nuclear Function Research Sub Category Histones Chromatin Biology |
| Quality【质量】 |
routinely evaluated by immunoblot on U2OS cells lysed in RIPA with 0.1% SDS and sonicated
|
| Linkage【联系】 |
Replaces: MABE552
|
| Physical form【外形】 |
Unpurified
Protein G Purified immunoglobulin in Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative. |
| Analysis Note【分析说明】 |
Control
U2OS cell lysate |
| Other Notes【其他说明】 |
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
|
| Legal Information【法律信息】 |
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| biological source【生物来源】 |
mouse
|
| antibody form【抗体形式】 |
ascites fluid
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| antibody product type |
primary antibodies
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| clone【克隆】 |
MG44, monoclonal
|
| species reactivity |
human, mouse
|
| manufacturer/tradename |
Upstate
?
|
| technique(s) |
ChIP: suitable
immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 |
IgG
|
| NCBI accession no.【NCBI登记号】 |
NM_003173.2
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| UniProt accession no.【UniProt登记号】 |
O43463
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| shipped in【运输】 |
dry ice
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| Gene Information |
human ... SUV39H1(6839)
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半岛bd体育手机客户端 说明
| Target description【目标描述】 |
50 kDa
|
| Storage and Stability【储存及稳定性】 |
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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| Disclaimer【免责声明】 |
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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安全信息
| Storage Class Code【储存分类代码】 |
10 - Combustible liquids
|
| WGK |
WGK 1
|
