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LDN-211904-Calbiochem
| 半岛bd体育手机客户端 编号： | 4084097 |
| 规格： | LDN-211904 modulates the biological activity of EphB3 receptor tyrosine kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| 包装规格： | 5 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
LDN-211904-Calbiochem
N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate, EphB3 inhibitor, LDN-211904
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
21H
21ClN
4O
5
|
| Molecular weight |
444.87
|
| MDL number |
MFCD28023573
|
| General description【一般描述】 |
A pyrazolo[1,5-a]pyridine derivative that acts as an potent and reversible EphB3 receptor tyrosine kinase inhibitor with an IC
50of 79 nM with good mouse liver microsomal stability and aqueous solubility. Shown to suppress EphB3-induced autophosphorylation of EphB3 receptor at 10 ?M in cells. When profiled against a panel of 288 kinases at 5 ?M, found to also inhibit most of the Eph (Erythropoietin-producing hepatocellular carcinoma) receptor kinases including EphA1, EphA2, EphA3, EphA4, EphA5, EphA8, EphB1, EphB2, EphB3, EphB4 and other tyrosine kinases, but not EphA6 and EphA7, and is non-inhibitory towards non-RTK kinases screened except for p38α, p38β, and Qik.
|
| Biochem/physiol Actions【生化/生理作用】 |
Cell permeable: yes
Primary Target Erythropoietin-producing hepatocellular carcinoma (Eph) Reversible: yes |
| Warning【警告】 |
Toxicity: Standard Handling (A)
|
| Reconstitution【重悬】 |
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
|
| Other Notes【其他说明】 |
Qiao, L., et al. 2011,
Bioorg. Med. Chem. Lett.
19,6122
|
| Legal Information【法律信息】 |
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
|
半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| Assay【测定】 |
≥99% (HPLC)
|
| form【形式】 |
solid
|
| potency【效能】 |
79 nM IC
50
|
| manufacturer/tradename |
Calbiochem
?
|
| storage condition【储存条件】 |
OK to freeze
protect from light |
| color【颜色】 |
off-white
|
| solubility【溶解性】 |
DMSO: 50 mg/mL, clear, nearly colorless
|
| shipped in【运输】 |
ambient
|
| storage temp.【储存温度】 |
2-8℃
|
| SMILES string |
O=C(NC1=CC=CC=C1Cl)C2=CN=C3C=CC(C4CCNCC4)=CN32.OC(C(O)=O)=O
|
| packaging【包装】 |
5 mg in Glass bottle
|
安全信息
| Storage Class Code【储存分类代码】 |
11 - Combustible Solids
|
| WGK |
WGK 2
|
