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JAK3/GSK-3β/PKCα Inhibitor-CAS 1260181-14-3-Calbiochem
| 半岛bd体育手机客户端 编号： | 4083884 |
| 规格： | The JAK3/GSK-3β/PKCα Inhibitor, also referenced under CAS 1260181-14-3, controls the biological activity of JAK3/GSK-3β/PKCα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 1260181-14-3 |
| 包装规格： | 5 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
1260181-14-3
JAK3/GSK-3β/PKCα Inhibitor-CAS 1260181-14-3-Calbiochem
JAK3 Inhibitor XII, NIBR3049, 3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione
3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, JAK3 Inhibitor XII, NIBR3049
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
27H
25F
3N
4O
4
|
| Molecular weight |
526.51
|
| MDL number |
MFCD19380092
|
| General description【一般描述】 |
A cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3β, JAK3, PKCα and PKCθ (IC
50= 3, 8, 13 and 68 nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC
50= 1.017, 2.55 and 8.055 ?M, respectively). Shown to efficiently block interleukin stimulated STAT5 phosphorylation and T cell costimulation (IC
50= 0.525, 1.294 and 0.689 ?M in IL15-MO7, IL2-CTLL and TCR/CD28-Jurkat cells, respectively).
|
| Warning【警告】 |
Toxicity: Standard Handling (A)
|
| Other Notes【其他说明】 |
Haan, C., et al. 2011.
Chem. Biol.
18,314.
Thoma, G., et al. 2011. J. Med. Chem. 54,284. |
| Legal Information【法律信息】 |
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
|
半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| Assay【测定】 |
≥95% (HPLC)
|
| form【形式】 |
solid
|
| manufacturer/tradename |
Calbiochem
?
|
| storage condition【储存条件】 |
OK to freeze
protect from light |
| color【颜色】 |
yellow
|
| solubility【溶解性】 |
DMSO: soluble
|
| shipped in【运输】 |
ambient
|
| storage temp.【储存温度】 |
2-8℃
|
| SMILES string |
O=C1NC(C(C2=CNC3=C2C=CC=C3)=C1C4=CC(N5CCN(C(C(C)(C)O)=O)CC5)=CC=C4C(F)(F)F)=O
|
| packaging【包装】 |
5 mg in Glass bottle
Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 |
11 - Combustible Solids
|
| WGK |
WGK 3
|
