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中心 > 71997-40-5， Oxidized ATP (oATP)-CAS 71997-40-5-Calbiochem
Oxidized ATP (oATP)-CAS 71997-40-5-Calbiochem
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| 半岛bd体育手机客户端 编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083441 | 25 MG | 3010 |
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别名
71997-40-5
Oxidized ATP (oATP)-CAS 71997-40-5-Calbiochem
Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H14N5O13P3 |
| Molecular weight | 505.17 |
| MDL number | MFCD00056956 |
| General description【一般描述】 | A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts. |
| Biochem/physiol Actions【生化/生理作用】 | Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Other Notes【其他说明】 | Vergani, A., et al. 2013. Diabetes62, 1665. DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378. Wiley, J.S., et al. 1994. Br. J. Pharmacol.112, 946. Murgia, M., et al. 1992. J. Biol. Chem.268, 8199. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
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性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | water: 50 mg/mL |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
