您的位置：首页 > 半岛bd体育手机客户端
中心 > Anti-HMGCR antibody produced in rabbit
Anti-HMGCR antibody produced in rabbit
| 半岛bd体育手机客户端 编号： | 3367876 |
| 规格： | ~1.0 mg/mL, affinity isolated antibody |
| 包装规格： | 200 μL |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端
别名
Anti-HMGCR antibody produced in rabbit
Anti-3-hydroxy-3-methylglutaryl-CoA reductase, LDLCQ3
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) codes for a part of the statin-binding domain of the enzyme. This gene is located on human chromosome 5q13. HMGCR has a molecular mass of 97 kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues. |
| Immunogen【免疫原】 | synthetic peptide corresponding to an internal sequence of human HMGCR, conjugated to KLH. The corresponding sequence is identical in human HMGCR isoform 2 and has 87% sequence identity in mouse HMGCR and 81% identity in rat HMGCR. |
| Application【应用】 | Anti-HMGCR antibody produced in rabbit has been used in western blotting. |
| Biochem/physiol Actions【生化/生理作用】 | 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) plays a major role in mevalonate biosynthesis, which is a rate limiting step of cholesterol biosynthesis in the liver. Additionally, it also plays a key role in various biological process such as, embryogenesis and cancer. Elevated expression of the gene is associated with the development of gastric cancer(GC) and glioblastoma cells. Thus, HMGCR can be considered as a potent therapeutic target for GC and glioblastoma. Polymorphism in HMGCR results in late-onset Alzheimer′s disease. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
半岛bd体育手机客户端
性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 100 kDa |
| species reactivity | human |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 1.0-2.0 μg/mL using mevastatin-treated HepG2 cells. western blot: 1.5-3.0 μg/mL using extracts of mevastatin-treated HepG2 cells. |
| UniProt accession no.【UniProt登记号】 | P04035 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... HMGCR(3156) |
半岛bd体育手机客户端
说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
