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Anti-ABIN3 antibody produced in rabbit

半岛bd体育手机客户端 编号:3342680
规格:affinity isolated antibody, buffered aqueous solution
包装规格:100 μG
半岛bd体育手机客户端 类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
半岛bd体育手机客户端 价格
半岛bd体育手机客户端 编号包装单位单价(元)国内现货国外库存询价单
3342680100 μG5040
半岛bd体育手机客户端 别名

Anti-ABIN3 antibody produced in rabbit

Anti-LIND

Anti-TNFAIP3 interacting protein 3

Anti-TNIP3

Anti-A20-binding inhibitor of NF-kappaB activation 3

Anti-Listeria-induced gene protein

基本信息
NACRES
NA.41
Immunogen【免疫原】
ABIN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Linkage【联系】
The action of this antibody can be blocked using blocking peptide SBP3500087.
Physical form【外形】
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
半岛bd体育手机客户端 性质
biological source【生物来源】
rabbit
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
species reactivity
human, mouse
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_079149
UniProt accession no.【UniProt登记号】
Q96KP6
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... TNIP3(79931)
半岛bd体育手机客户端 说明
Target description【目标描述】
The nuclear factor NF-kB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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