您的位置：首页 > 半岛bd体育手机客户端 中心 > 518303-20-3， UMI-77
UMI-77
| 半岛bd体育手机客户端 编号： | 3257831 |
| 规格： | ≥98% (HPLC) |
| CAS NO： | 518303-20-3 |
| 包装规格： | 5 MG，25 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
518303-20-3
UMI-77
2-[[4-[[(4-Bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
18H
14BrNO
5S
2
|
| Molecular weight |
468.34
|
| MDL number |
MFCD03471890
|
| PubChem Substance ID【PubChem化学物质编号】 |
329825918
|
| NACRES |
NA.77
|
| Biochem/physiol Actions【生化/生理作用】 |
UMI-77 is an inhibitor of Induced myeloid leukemia cell differentiation protein Mcl-1, a member of the Bcl-2 family that inhibits apoptosis. UMI-77 acts by binding to the BH3-binding groove of Mcl-1, blocking the heterodimerization of Mcl-1/Bax and Mcl-1/Bak. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. It inhibited cell growth and induced apoptosis in pancreatic cancer cells.
|
半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| Assay【测定】 |
≥98% (HPLC)
|
| form【形式】 |
powder
|
| color【颜色】 |
white to beige
|
| solubility【溶解性】 |
DMSO: 20 mg/mL, clear
|
| storage temp.【储存温度】 |
?20℃
|
| SMILES string |
OC1=C(SCC(O)=O)C=C(NS(C2=CC=C(Br)C=C2)(=O)=O)C3=CC=CC=C31
|
| InChI |
1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)
|
| InChI key |
WUGANDSUVKXMEC-UHFFFAOYSA-N
|
| packaging【包装】 |
5, 25 mg in glass bottle
|
安全信息
| Pictograms【象形图】 |
GHS05,GHS07
|
| Signal word【警示用语：】 |
Danger
|
| Hazard Statements |
H302 - H315 - H318 - H335
|
| Precautionary Statements |
P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
|
| Hazard Classifications【危险分类】 |
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
|
| Target Organs【靶器官】 |
Respiratory system
|
| Storage Class Code【储存分类代码】 |
13 - Non Combustible Solids
|
| WGK |
WGK 3
|
