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PCNA-I1
| 半岛bd体育手机客户端 编号： | 3179345 |
| 规格： | ≥98% (HPLC) |
| CAS NO： | 1364915-48-9 |
| 包装规格： | 5 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
1364915-48-9
PCNA-I1
N-(3-Methylthiophene-2-carboxylic acid)-N′-[(3-hydroxy-2-naphthalenyl)methylene]hydrazide
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
17H
14N
2O
2S
|
| Molecular weight |
310.37
|
| NACRES |
NA.77
|
| Biochem/physiol Actions【生化/生理作用】 |
PCNA-I1 is a small molecule PCNA inhibitor that selectively binds to PCNA trimers and reduces the association of PCNA with chromatin. PCNA-I1 induces S and G2/M phase cell cycle arrest in tumor cells with greater efficacy than non-transformed cells.
Proliferating cell nuclear antigen-l1 (PCNA) is a member of the scaffold B class. It acts as a linker at the monomer-monomer interface. PCNA-I1 has the ability to block the development of primary cultures of bone marrow mesenchymal stem cells, endothelial cells, lymphocytes, mammary epithelial cells and prostate epithelial cells. |
半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| Assay【测定】 |
≥98% (HPLC)
|
| form【形式】 |
powder
|
| color【颜色】 |
white to beige
|
| solubility【溶解性】 |
DMSO: 10 mg/mL, clear
|
| storage temp.【储存温度】 |
2-8℃
|
| packaging【包装】 |
5, 25 mg in glass bottle
|
安全信息
| Pictograms【象形图】 |
GHS07
|
| Signal word【警示用语：】 |
Warning
|
| Hazard Statements |
H302
|
| Hazard Classifications【危险分类】 |
Acute Tox. 4 Oral
|
| Storage Class Code【储存分类代码】 |
13 - Non Combustible Solids
|
| WGK |
WGK 3
|
