您的位置：首页 > 半岛bd体育手机客户端 中心 > 133052-90-1， GF 109203X
GF 109203X
| 半岛bd体育手机客户端 编号： | 3090610 |
| 规格： | synthetic, ≥90% (HPLC) |
| CAS NO： | 133052-90-1 |
| 包装规格： | 1 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 价格
查看更多规格...
| 半岛bd体育手机客户端 编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3090610 | 1 MG | 11190 |
半岛bd体育手机客户端 别名
133052-90-1
GF 109203X
3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide
Bisindolylmaleimide I
3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
25H
24N
4O
2
|
| Molecular weight |
412.48
|
| MDL number |
MFCD00236428
|
| PubChem Substance ID【PubChem化学物质编号】 |
329799908
|
| NACRES |
NA.77
|
| Application【应用】 |
GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats.
|
| Biochem/physiol Actions【生化/生理作用】 |
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca
2+resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca
2+resorption elicited by a number of agents, but GF109203X counteracted that enhancement.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM. |
| Quantity【数量】 |
For PKC inhibition, typically used at a concentration of 0.1-10 μM.
|
半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| biological source【生物来源】 |
synthetic
|
| Assay【测定】 |
≥90% (HPLC)
|
| solubility【溶解性】 |
DMSO: soluble (~1 mg/ml)
|
| storage temp.【储存温度】 |
2-8℃
|
| SMILES string |
CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15
|
| InChI |
1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
|
| InChI key |
QMGUOJYZJKLOLH-UHFFFAOYSA-N
|
安全信息
| Pictograms【象形图】 |
GHS08
|
| Signal word【警示用语：】 |
Warning
|
| Hazard Statements |
H351
|
| Precautionary Statements |
P201 - P202 - P280 - P308 + P313 - P405 - P501
|
| Hazard Classifications【危险分类】 |
Carc. 2
|
| Supp Hazards【补充剂危害】 |
EUH019
|
| Storage Class Code【储存分类代码】 |
11 - Combustible Solids
|
| WGK |
WGK 3
|
