半岛bd体育手机客户端 说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flurbiprofen is a non-selective, non-steroidal anti-inflammatory drug (NSAID) that is widely used against rheumatoid arthritis. It is also effective against vernal keratoconjunctivitis, post-operative ocular inflammation, herpetic stromal keratitis, excimer laser photorefractive keratectomy and ocular gingivitis.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Flurbiprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological samples by various analytical techniques.

生化/生理作用

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. TheSenantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while theRenantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance withISO 17034andISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA3047 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

线性分子式	C6H5C6H3(F)CH(CH3)CO2H
分子量	244.26
EC 号	225-827-6
MDL编号	MFCD00079303
PubChem化学物质编号	329823420
NACRES	NA.24

半岛bd体育手机客户端 性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
包装	pkg of 500 mg
technique(s)	HPLC: suitable gas chromatography (GC): suitable
mp	110-112 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to PhEur F0285200 traceable to USP 1285750
储存温度	2-30℃
SMILES string	CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI	1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI key	SYTBZMRGLBWNTM-UHFFFAOYSA-N
Gene Information	human ... PTGS1(5742), PTGS2(5743)

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable