半岛bd体育手机客户端 说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Propyl gallate is a synthetic phenolic antioxidant (SPA) utilized in food additives to inhibit or regulate the lipid oxidation. SPAs are cost-effective, largely available and highly efficient in comparison to their natural counterparts.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Propyl gallate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and fatty liquids by chromatography and spectrophotometry.
在荧光显微术中用作抗淬灭剂，以减少罗丹明和荧光素等荧光探针的光漂白。

生化/生理作用

表现出抗菌活性的抗氧化剂。据报道，五倍子酸丙酯是一种有效的、抗氧化剂类体内外护肝剂。另据证明，它能防止神经元凋亡，阻止暴露于 FeSO₄/GA 的神经元死亡，以及在一定程度上防止 TNF-诱导的内皮细胞凋亡。但是，当五倍子酸丙酯浓度高于 0.25μM，同时存在 5μM 及更高浓度的铜时，会诱导 DNA 单链断裂。另有报道称，使用浓度 >1mM 的五倍子酸丙酯进行离体大鼠肝细胞培养会诱导细胞死亡，而 >0.5mM 的较低浓度的五倍子酸丙酯导致了可溶性低分子量 DNA 片段的 ladder 形成，这是细胞凋亡的特征。
表现出抗菌活性的抗氧化剂。据报道，五倍子酸丙酯是一种有效的、抗氧化剂类体内外护肝剂。另据证明，它能防止神经元凋亡，阻止暴露于 FeSO₄/GA 的神经元死亡，以及在一定程度上防止 TNF-诱导的内皮细胞凋亡。

重悬

用甘油:PBS (9:1) 配成 0.1M 的溶液

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance withISO 17034andISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA8981 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

线性分子式	3,4,5-(HO)3C6H2CO2CH2CH2CH3
分子量	212.20
Beilstein	1877976
EC 号	204-498-2
MDL编号	MFCD00002196
PubChem化学物质编号	329823139
E编号	E310
NACRES	NA.24

半岛bd体育手机客户端 性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable gas chromatography (GC): suitable
mp	146-149 ℃ (lit.)
application(s)	cleaning products cosmetics flavors and fragrances food and beverages personal care pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to PhEur P3640000 traceable to USP 1576800
储存温度	2-30℃
SMILES string	CCCOC(=O)c1cc(O)c(O)c(O)c1
InChI	1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3
InChI key	ZTHYODDOHIVTJV-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H317 - H318 - H410
预防措施声明	P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	368.6 °F - closed cup
闪点(C)	187 ℃ - closed cup