半岛bd体育手机客户端 说明
一般描述
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Desloratadine is one of the orally active, highly selective peripheral H1receptor antagonists that does not exert any significant effect on the central and autonomic nervous systems. The potency of desloratadine is more than that of loratadine and it exhibits substantial overall pharmacological profile.
应用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Desloratadine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by various chromatography techniques.
生化/生理作用
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.
分析说明
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance withISO 17034andISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAC2775 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
法律信息
Clarinex is a registered trademark of Schering Corp.
基本信息
| 经验(实验)分子式 | C19H19ClN2 |
| 分子量 | 310.82 |
| MDL编号 | MFCD00871949 |
| PubChem化学物质编号 | 329823552 |
| NACRES | NA.24 |
半岛bd体育手机客户端 性质
| 质量水平 | 300 |
| 等级 | certified reference material pharmaceutical secondary standard |
| CofA | current certificate can be downloaded |
| 包装 | pkg of 1 g |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| application(s) | pharmaceutical (small molecule) |
| 格式 | neat |
| 药典可追溯性 | traceable to PhEur Y0001584 traceable to USP 1173042 |
| 储存温度 | 2-30℃ |
| SMILES string | Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1 |
| InChI | 1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 |
| InChI key | JAUOIFJMECXRGI-UHFFFAOYSA-N |
| Gene Information | human ... HRH1(3269) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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