Technical Notes:
1. Biaryl bisphosphine ligand with narrow dihedral angle. The DM-S EGPHOS? ligand, as the ruthenium complex, gives superior
enantioselectivity and diastereoselectivity in the asymmetric hydrogenation of a-substituted-?-ketoesters. See 15-0066.
2.Ruthenium catalyzed enantioselective synthesis of ? amino acids by hydrogenation
3.Ruthenium catalyzed asymmetric hydrogenation of 3-quinuclidinone. See 44-0098 for Ru catalyst.
References:
1. U.S. Pat. 7626034.
2. U.S. Pat 7462722.
Strem