Technical Notes :
1. Biaryl bisphosphine ligand. The Ha-BINAP ligand, as the ruthenium complex, catalyzes hydrogenation of unsaturate carboxylic acids to a higher ee than does BINAP. (Ref. 1,2)
2. The ruthenium catalyzed hydrogenation of aryl propenoic acid to produce the drug lbuprofen.
References:
1. J. Org. Chem.. 1996. 61. 5510
2. Topics Organometal. Chem. 2004, 6. 63 (review).
Strem