Technical Notes:

1. Biaryl bisphos phine ligand with narrow dihedral angle. The SEGPHOS? ligand has been applied to a variety of metal catalyzed reactions. In many cases, yields and enantios electivities, exceed results obtained earlier using BINAP

2.As ruthenium complex, SEGPHC S? generally gives higher levels of chiral induction in as ymmetric hydrogenations of a,?,and y-functionalized ketones. See ruthenium complexes 44-0096, 44-0518, 44-01 68

3.Used in Rh-catalyzed transformations such as: (a) 1,4-addition of boronic acids to coumarins, (b) addition of titanium reagents to imines,' (c) cotrimerization of alkenes and acetylenes,o (d) double2+2+2cycloaddition," (e) indanone formation.a,

4.Used in Pd-catalyzed transformations such as: (a) cycloaddition of 1,6-enyne, (b) arylative cyclization of allenyl aldehydes with boronic acids,13 (c) synthesis of chromans.

5.Used in Cu-catalyzed transformations such as: (a) nitroso Diels-Alder,' (b) reductive aldol

6.condensation, (c) conjugate reduction of unsaturated sulfones, and phophonates

7.Iridium-catalyzed asymmetric hydrogenation of quinolines activated by chloroformates

8.Iridium-catalyzed asymmetric transfer hydrog enation used in polyketide construction.

9.Rhodium-catalyzed asymmetric hydroarylation of 3-pyrrolines.

10.P alladium-catalyzed regio- and enantioselective dearomatization of pyrroles to 2H-pyrroles.' Rhodium-catalyzed as ymmetric synthesis of cyclopentanols.0

11. Silver-catalyzed as ymmetric Mannich-type reac tion.