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1994骞达紝Marc Wilkins鍦⊿iena鍙屽悜鍑濊兌鐢垫吵(two-dimensional electrophoresis锛?-DE)浼氳涓婃渶鏃╂彁鍑轰簡铔嬬櫧璐ㄧ粍(proteome)姒傚康锛屽苟浜?995骞?鏈堢殑Electrophoresis鏉傚織涓婂彂琛ㄣ€傞殢鐫€楂橀€氶噺銆侀珮鐏垫晱搴︺€侀珮鍒嗚鲸鐜囩敓鐗╄川璋辨妧鏈殑鍑虹幇锛岃泲鐧借川缁勫鎶€鏈彇寰楅閫熷彂灞曪紝浜轰滑涓嶅啀婊¤冻浜庡涓€涓粏鑳炴垨缁勭粐鐨勮泲鐧借川杩涜瀹氭€х爺绌讹紝鑰屾槸鐫€鐪间簬铔嬬櫧璐ㄩ噺鐨勭爺绌讹紝浜庢槸铔嬬櫧璐ㄧ粍瀛︽蹇靛氨琚彁鍑猴紝骞跺緱鍒颁簡骞挎硾鐨勫簲鐢ㄣ€侟/span>

铔嬬櫧璐ㄧ粍瀛?Proteomics)鏄泲鐧借川(protein)涓 鍩哄洜缁勫(genomics)涓や釜璇嶇殑缁勫悎浣擄紝琛ㄧず鈥滀竴绉嶅熀鍥犵粍鎵€琛ㄨ揪鐨勫叏濂楄泲鐧借川鈥濓紝鍗冲寘鎷竴绉嶇粏鑳炰箖鑷充竴绉嶇敓鐗╂墍琛ㄨ揪鐨勫叏閮ㄨ泲鐧借川銆傝泲鐧借川缁勫鐮旂┒锛屽氨鏄鎶婁竴涓熀鍥犵粍琛ㄨ揪鐨勭粷澶у鏁拌泲鐧借川鎴栦竴涓鏉傜殑娣峰悎浣撶郴涓粷澶у鏁拌泲鐧借川杩涜绮剧‘鐨勫畾閲忓拰閴村畾銆侟/span>

铔嬬櫧璐ㄧ粍鏈川涓婃寚鐨勬槸鍦ㄥぇ瑙勬ā姘村钩涓婄爺绌惰泲鐧借川鐨勭壒寰侊紝鍖呮嫭铔嬬櫧璐ㄧ殑琛ㄨ揪姘村钩锛岀炕璇戝悗鐨勪慨楗帮紝铔嬬櫧涓庤泲鐧界浉浜掍綔鐢ㄧ瓑锛岀敱姝よ幏寰楄泲鐧借川姘村钩涓婄殑鍏充簬鐤剧梾鍙戠敓锛岀粏鑳炰唬璋㈢瓑杩囩▼鐨勬暣浣撹€屽叏闈㈢殑璁よ瘑銆傝泲鐧借川缁勫鏄竴闂ㄤ互鍏ㄩ潰鐨勮泲鐧借川鎬ц川鐮旂┒涓哄熀纭€锛屽湪铔嬬櫧璐ㄦ按骞冲鐤剧梾鏈虹悊銆佺粏鑳炴ā寮忋€佸姛鑳借仈绯荤瓑鏂归潰杩涜鎺㈢储鐨勭瀛︺€傜洰鍓嶆渶鏂扮殑iTRAQ铔嬬櫧瀹氶噺鍒嗘瀽鎶€鏈湪姝ゅ熀纭€涓婅鎻愬嚭锛屽苟琚緱鍒板箍娉涘簲鐢ㄣ€侟/span>

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