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位置: 首页> 品牌> Sigma-Aldrich> Anti-TYMS antibody produced in rabbit

Anti-TYMS antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV48543
规格纯度
affinity isolated antibody
价格
6305.78 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-TYMS antibody produced in rabbit
Anti-TSase
Anti-thymidylate synthetase
Anti-TMS
Anti-MGC88736
Anti-HsT422
Anti-TS
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

TYMS codes for thymidylate synthetase that catalyzes the methylation of deoxyuridylate to deoxythymidylate. This reaction maintain the dTMP pool for DNA replications and repair. Variations in TYMS have been implicated in fluoropyrimidine toxicity.
Rabbit Anti-TYMS antibody recognizes bovine, human, mouse, and rat TYMS.

免疫原

Synthetic peptide directed towards the C terminal region of human TYMS

应用

Rabbit Anti-TYMS antibody is suitable for western blot applications at a concentration of 0.25 μg/ml.

生化/生理作用

TYMS catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-47 CR601528.1 1-47 48-1099 X02308.1 14-1065 1100-1603 BC083512.1 1067-1570

序列

Synthetic peptide located within the following region: HIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKME

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 36 kDa
species reactivity rat, dog, mouse, bovine, pig, human
浓度 0.5 mg - 1 mg/mL
technique(s) western blot: suitable
NCBI登记号 NP_001062
UniProt登记号 P04818
运输 wet ice
储存温度 ?20℃
Gene Information human ... TYMS(7298)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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