Anti-TPX2 antibody produced in rabbit

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一般描述

TPX2, microtubule-associated, homolog (Xenopus laevis) (DIL2, HCA519) is a highly conserved microtubule-associated protein (MAP) involved in spindle regulation via processes such as microtubule nucleation, bundling and stabilization, Aurora A kinase activation, kinesin-5 binding and kenesin-12 recruitment.

特异性

Anti-TPX2 polyclonal antibody reacts with bovine, canine, human, rat, and mouse TPX2, microtubule-associated, homolog proteins.

免疫原

Synthetic peptide directed towards the C terminal region of human TPX2

应用

Anti-TPX2 polyclonal antibody is used to tag TPX2, microtubule-associated, homolog protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of TPX2, microtubule-associated, homolog in the management of microtubule function and spindle dynamics during the cell cycle.

生化/生理作用

TPX2 binding decreases the size and accessibility of a hydrophobic pocket, adjacent to the ATP site, to inhibitors.

序列

Synthetic peptide located within the following region: LSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQK

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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