Anti-TAF15 (AB2) antibody produced in rabbit

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特异性

Anti-TAF15 (AB2) polyclonal antibody reacts with human, mouse, rat, and bovine TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa transcription factors.

免疫原

Synthetic peptide directed towards the N terminal region of human TAF15

应用

Anti-TAF15 (AB2) polyclonal antibody is used to tag TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa in RNA polymerase II transcription and early RNA processing.

生化/生理作用

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF15 encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.

特点和优势

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa (TAF15, Np13, TAF2N, TAF1168, RBP56) is a subunit of transcription factor IID (TFIID) present in a subset of TFIID complexes which coordinates the activities associated with transcription by RNA polymerase II. TAF15 is known to associate with spliceosomal U1 snRNP complex potentially linking transcription with RNA processing.

序列

Synthetic peptide located within the following region: HQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDN

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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