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位置: 首页> 品牌> Sigma-Aldrich> Anti-SMURF2 (N-term) antibody produced in rabbit

Anti-SMURF2 (N-term) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300011
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
4618.16 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-SMURF2 (N-term) antibody produced in rabbit
Anti-Smad ubiquitination regulatory factor 2
Anti-Ubiquitin--protein ligase SMURF2
Smad-specific E3 ubiquitin ligase 2
Anti-HSMURF2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

SMURF2, a 748-amino acid ubiquitin E3 ligase that is 83% identical to SMURF1, codes for a C2-WW-HECT domain ubiquitin ligase that associates constitutively with SMAD7. Binding to SMAD7 induces export of SMURF2 and recruitment to the activated transforming growth factor-beta receptor (TGFBR), where it causes receptor and SMAD7 degradation. A strong interaction of second and third SMURF2 WW domains has been identified with SMAD1, SMAD2, and SMAD3, but not SMAD4. Western blot analysis showed that SMURF2 selectively downregulates the transcription of SMAD2 and SMAD1, but not SMAD3. The nuclear SMURF2/phosphorylated SMAD2 interaction is requires TGFB1.

免疫原

SMURF2 (SUF2_HUMAN, 10-46)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SMURF2.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity mouse, human
technique(s) immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI登记号 NP_073576
UniProt登记号 Q9HAU4
运输 dry ice
储存温度 ?20℃
Gene Information human ... SMURF2(64750)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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