Anti-SH3GLB1 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

SH3GLB1 (SH3-domain GRB2-like endophilin B1) is a pro-apoptotic Bax binding protein belonging to the endophilin B family. It consists of an N-BAR (Bin/Amphiphysin/Rvs) domain with lipid binding ability and a C-terminal SH3 domain with proline-rich region binding capacity.

免疫原

The immunogen for anti-SH3GLB1 antibody: synthetic peptide derected towards the N terminal of human SH3GLB1

应用

Anti-SH3GLB1 antibody produced in rabbit is suitable for indirect ELISA and western blot analysis.

生化/生理作用

SH3GLB1 (SH3-domain GRB2-like endophilin B1) is a tumor suppressor gene associated with several activities such apoptosis, autophagy, and mitochondrial morphology. It also functions in the endocytic degradation of EGFR (epidermal growth factor receptor) and chemotactic migration in breast cancer cells. Deficiency of SH3GLB1 leads to suppressed programmed cell death and promotes tumorigenesis. It also delays EGFR degradation and sustains Erk1/2 activation in response to EGF stimulation. In breast cancer cells, it promotes EGFR degradation by regulating endosome maturation.

序列

Synthetic peptide located within the following region: KIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTE

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	40 kDa
species reactivity	guinea pig, mouse, bovine, rat, human, rabbit, dog, horse
technique(s)	western blot: suitable
NCBI登记号	NM_019464
UniProt登记号	Q9Y371
运输	wet ice
储存温度	?20℃
Gene Information	human ... SH3GLB1(51100) mouse ... Sh3glb1(54673)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable