半岛bd体育手机客户端 说明
一般描述
Ring-box 1 (RBX1) gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over (provided by RefSeq). Ring-box 1 (RBX1) gene is located on human chromosome 22q13.2. RBX1 is a component of SCF (Skp1, Cullins, F-box proteins) E3 ubiquitin ligases. RBX1 is a14 kDa protein with a ring finger domain (C3H2C3), essential for ubiquitin ligation.
免疫原
RBX1 (AAH01466, 1 a.a. ~ 108 a.a) full-length human protein.
Sequence
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
生化/生理作用
Ring-box 1 (RBX1) mediates neddylation of cullin-1(CUL1). RBX1 regulates protein turnover. RBX1 is a potential anticancer target. Mutations in RBX1 is linked to tumorigenesis and tumor progression. RBX1 acts as a drug target for esophageal cancer. RBX1 has a role in bladder urothelial cell carcinoma (UCC) carcinogenesis and progression.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 11.99 kDa |
| species reactivity | human |
| technique(s) | indirect immunofluorescence: suitable western blot: 1 μg/mL |
| NCBI登记号 | BC001466 |
| UniProt登记号 | P62877 |
| 运输 | dry ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... RBX1(9978) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
