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Anti-PRPF4 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1400336
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
4618.16 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-PRPF4 antibody produced in mouse
Anti-HPRP4P
Anti-Prp4p
Anti-HPRP4
Anti-PRP4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM

免疫原

PRPF4 (NP_004688, 1 a.a. ~ 522 a.a) full-length human protein.

Sequence
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE

生化/生理作用

PRPF4 (Pre-mRNA processing factor 4) is a spliceosomal protein highly involved in the pre-mRNA splicing. It acts as a component of U4/U5/U6 tri-snRNP complex during the formation of active core of the spliceosome. Mutation in PRPF4 causes an autosomal dominant disorder, retinitis pigmentosa (RP) characterized with progressive loss of photoreceptors. PRPF4 also plays a role in cell mitosis by participating in the regulation of mitotic spindle assembly.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity human
technique(s) indirect immunofluorescence: suitable
western blot: 1 μg/mL
UniProt登记号 O43172
运输 dry ice
储存温度 ?20℃
Gene Information human ... PRPF4(9128)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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