Anti-PPA1 antibody produced in rabbit

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一般描述

Pyrophosphatase (inorganic) 1 (PPA1) catalyzes the hydrolysis of pyrophosphate to inorganic phosphate in cells.
Rabbit Anti-PPA1 antibody recognizes bovine, human, mouse, and rat PPA1.
PPA1 (Inorganic pyrophosphatase 1) is a 32kDa protein consisting of an aspartate-rich region. It is expressed in all the tissues and mapped on chromosome 10.

免疫原

Synthetic peptide directed towards the N terminal region of human PPA1

应用

Rabbit Anti-PPA1 antibody is suitable for western blot applications at a concentration of 0.5mg-1mg/mL.

生化/生理作用

PPA1 (pyrophosphatase 1) facilitates hydrolytic conversion of pyrophosphate to orthophosphate. Study shows its tumor-specific protein expression in gastric cancer cells, thus, it has been suggested that PPA1 can be a potential tumor-specific marker in gastric cancers. PPA1 is also involved in the regulation of pancreatic ductal HCO₃^-secretion. It helps to organize transepithelial HCO₃^-prior to fluid secretion from human serous-like airway cells. In addition, it also controls anion exchanger (AE) activity by activating CFTR (cystic fibrosis transmembrane conductance regulator)/pendrin at the apical membrane and inhibiting the basolateral AE by cAMP agonists.

序列

Synthetic peptide located within the following region: PRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQT

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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