Anti-Parkin antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Anti-Parkin Antibody detects endogenous levels of total Parkin protein.
Parkin RBR E3 ubiquitin protein ligase (PARK2) is a putative tumor suppressor gene. It possesses an amino-terminal region containing the Ubl (ubiquitin like) domain and a carboxy-terminal region with four zinc coordinating domains. Parkin is a 465 amino acid protein, which is part of the ubiquitin-proteasome system that targets proteins for degradation. The gene encoding it is localized on human chromosome 6q25.2-q27.

免疫原

The antiserum was produced against synthesized peptide derived from human Parkin.

Immunogen Range:1-50

应用

Anti-Parkin antibody produced in rabbit has been used in western blotting.

生化/生理作用

The expression of parkin RBR E3 ubiquitin protein ligase (PARK2) has been found to be altered in various malignancies. Parkin has a neuroprotective E3 ligase activity and polyubiquitylates proteins before degradation. Mutations in the gene encoding it have been linked to autosomal recessive juvenile parkinson (ARJP) disease.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号

MFCD03702182

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen 51 kDa
species reactivity	rat, human, mouse
浓度	~1 mg/mL
technique(s)	ELISA: 1:5000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000
NCBI登记号	O60260
运输	wet ice
储存温度	?20℃
Gene Information	human ... PARK2(5071)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable