Anti-NDE1 antibody produced in rabbit

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一般描述

NDE1 codes for a protein that belongs to the nuclear distribution E (NudE) family. It forms a part of a multiprotein complex that modulates the function of dynein. Phoshorylated NDE1 is known to interact with NDEL1 and LIS1. NDE1 represses ciliogenesis and modulates cell cycle re-entry. Mutations in NDE1 have been linked to microcephaly with lissencephaly.
Rabbit Anti-NDE1 antibody recognizes chicken, human, mouse, rat, rabbit, zebrafish, bovine, and canine NDE1.

免疫原

Synthetic peptide directed towards the middle region of human NDE1

应用

Rabbit Anti-NDE1 antibody is suitable for western blot applications at a concentration of 1μg/ml.

生化/生理作用

NDE1 is required for centrosome duplication and formation and function of the mitotic spindle. It is essential for the development of the cerebral cortex. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex

序列

Synthetic peptide located within the following region: AHRGPSSSLNTPGSFRRGLDDSTGGTPLTPAARISALNIVGDLLRKVGAL

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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