Anti-LCK antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

LCK (Lymphocyte-specific protein tyrosine kinase) gene belongs to Src family of protein tyrosine kinases (PTKs) and is localized to cytoplasm and cell membrane. It is mapped on to chromosome 1 at 1p34.3 and is organized in 13 exons, out of which, 12 are coding exons whereas one is putative 5′-noncoding exon.

免疫原

Synthetic peptide directed towards the N terminal region of human LCK

应用

Anti-LCK antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

生化/生理作用

The protein encoded by the gene plays a pivotal role in the selection and maturation of developing T-cells. Lck binds to CD3ζ and inhibits CD59-triggered Ca²⁺signaling. It acts directly on TCR/CD3 pathway in Jurkat T cells and hence facilitates T cell responses.

序列

Synthetic peptide located within the following region: PSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLE

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	58 kDa
species reactivity	human, dog, rabbit, bovine, horse, mouse, guinea pig, rat
浓度	0.5 mg - 1 mg/mL
technique(s)	western blot: suitable
NCBI登记号	NP_005347
UniProt登记号	P06239
运输	wet ice
储存温度	?20℃
Gene Information	human ... LCK(3932)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable