Anti-FKBP8 (AB1) antibody produced in rabbit

半岛bd体育手机客户端 说明

免疫原

Synthetic peptide directed towards the N terminal region of human FKBP8

应用

Anti-FKBP8 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

生化/生理作用

FKBP8 gene encodes for FK506 binding protein 8, which is a membrane-anchored, tetratricopeptide repeat (TPR)-containing immunophilin that belongs to peptidylprolyl isomerase family and facilitates the cis/trans interconversion of peptidyl prolyl bonds. It also regulates the late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability. FKBP38 plays a crucial role in regulating the apoptosis as well as the function of Bcl-2. Overexpression of FKBP38 diminishes the reduction rate of Bcl-2 that leads to increase in intracellular Bcl-2 level and inhibits the apoptotic cell death. Further, FKBP8 directly interacts with the flexible loop domain of Bcl-2 that contains the caspase cleavage site and protects Bcl-2 from caspase-dependent degradation.

序列

Synthetic peptide located within the following region: GPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLS

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	45 kDa
species reactivity	mouse, dog, goat, human, horse, rat, guinea pig
浓度	0.5 mg - 1 mg/mL
technique(s)	immunohistochemistry: suitable western blot: suitable
NCBI登记号	NP_036313
UniProt登记号	Q14318
运输	wet ice
储存温度	?20℃
Gene Information	human ... FKBP8(23770)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable