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位置: 首页> 品牌> Sigma-Aldrich> Anti-FGD1 antibody produced in rabbit

Anti-FGD1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV31673
规格纯度
affinity isolated antibody
价格
5732.41 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-FGD1 antibody produced in rabbit
Anti-FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia)
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Facio-genital dysplasia protein (FGD1) is an upstream regulator of Rho GTPases and is involved in the normal development of embryos. It is also known to function as a guanine-nucleotide exchange factor which is specific for Cdc42Hs. FGD1 mutations have been implicated in Aarskog syndrome.
Rabbit Anti-FGD1 antibody recognizes canine, bovine, human, mouse, and rat FGD1.

免疫原

Synthetic peptide directed towards the C terminal region of human FGD1

应用

Rabbit Anti-FGD1 antibody has been used for western blotting assays at a concentration of 2.0μg/ml.

生化/生理作用

FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.

序列

Synthetic peptide located within the following region: WMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDKT

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 107 kDa
species reactivity human
浓度 0.5 mg - 1 mg/mL
technique(s) immunohistochemistry: suitable
western blot: suitable
NCBI登记号 NP_004454
UniProt登记号 P98174
运输 wet ice
储存温度 ?20℃
Gene Information human ... FGD1(2245)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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