Anti-AIRE (AB1) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

AIRE is a transcription factor that regulates the expression of autoantigens in T cells. Defects in AIRE have been linked to autoimmune polyendocrinopathy syndrome type 1 (APS1).
Rabbit Anti-AIRE (AB1) antibody recognizes human and bovine AIRE.

免疫原

Synthetic peptide directed towards the N terminal region of human AIRE

应用

Rabbit Anti-AIRE (AB1) antibody can be used for western blot applications at a concentration of 2μg/ml.

生化/生理作用

The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

序列

Synthetic peptide located within the following region: DFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPP

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	58 kDa
species reactivity	human
浓度	0.5 mg - 1 mg/mL
technique(s)	western blot: suitable
NCBI登记号	NP_000374
UniProt登记号	O43918
运输	wet ice
储存温度	?20℃
Gene Information	human ... AIRE(326)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable