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Anti-ABAT antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB2103347
规格纯度
affinity isolated antibody
价格
6305.78 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-ABAT antibody produced in rabbit
Anti-GABA-AT
Anti-NPD009
Anti-GABAT
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

4-aminobutyrate aminotransferase (ABAT) is a potent enzyme in gamma aminobutyric acid (GABA) metabolism. In the human chromosome, the gene ABAT is localized on 16p13.2.

免疫原

Synthetic peptide directed towards the middle region of human ABAT

生化/生理作用

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. ABAT is associated with salvage pathway for nucleoside production in mitochondria. Mutation leads to mitochondrial DNA depletion syndrome. ABAT is related to autism spectrum disorders.

序列

Synthetic peptide located within the following region: YRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATT

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 56 kDa
species reactivity human
浓度 0.5 mg - 1 mg/mL
technique(s) immunohistochemistry: suitable
western blot: suitable
NCBI登记号 NM_020686
UniProt登记号 P80404
运输 wet ice
储存温度 ?20℃
Gene Information human ... ABAT(18)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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