半岛bd体育手机客户端 说明
免疫原
The epitope recognized by PLA0198 maps to a region between residue 1 and 50 of human tyrosyl-DNA phosphodiesterase 1 using the numbering given in entry NP_001008744.1 (GeneID 55775).
外形
Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide
其他说明
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme that participates in the repair of DNA strand breaks associated with topoisomerase 1 (Top1) complexes. TDP1 catalyzes the removal of Top1 from DNA via the hydrolysis of the phosphodiester bond between the tyrosine residue of Top1 and the 3′ phosphate of DNA. Removal of Top1 is then followed by DNA repair. TDP1 has been proposed to play more general roles in DNA damage repair independent of the Top1 complex. TDP1 has been shown to associate with DNA ligase IIIalpha, a component of the DNA single-stranded break repair (SSBR) machinery. It is also able to remove glycolate from 3′-phosphoglycolate termini of double-stranded breaks and a variety of other 3′- adducts. Defects in TDP1 are associated with spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1), a disease associated with peripheral axonal motor and sensory neuropathy and distal muscular atrophy.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| 等级 | Powered by Bethyl Laboratories, Inc. |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:100- 1:500 immunoprecipitation (IP): 2-5 μg/mg western blot: 1:2,000- 1:10,000 |
| 登记号 | NP_001008744.1 |
| UniProt登记号 | Q9NUW8 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | rabbit ... TDP1(55775) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
