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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-STS-1 antibody produced in mouse

Monoclonal Anti-STS-1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1402643
规格纯度
clone 3G7, purified immunoglobulin, buffered aqueous solution
价格
4618.16 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-STS-1 antibody produced in mouse
KIAA1959
p70
MGC15437
STS-1
STS1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The STS1 (suppressor of T-cell receptor signaling 1) gene encodes a histidine tyrosine phosphatase, which is expressed ubiquitously. The protein contains an SH3 domain and an N-terminal ubiquitin associated domain. Its C-terminal domain is similar to the catalytic motif of phosphoglycerate mutase. The gene is also known as UBASH3B (ubiquitin associated and SH3 domain containing B) and TULA2 (T-cell ubiquitin ligand-2) and is mapped to human chromosome 11q24.1. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.

免疫原

UBASH3B (NP_116262.2, 344 a.a. ~ 441 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
DGVLERRPYEDQGLGETTPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPI

生化/生理作用

The STS1 (suppressor of T-cell receptor signaling 1) protein is involved in the dephosphorylation of Syk (spleen tyrosine kinase). This gene is known to induce metastasis and invasion in breast cancer by inhibiting the action of core binding factor and thereby, controls epidermal growth factor receptor activity. The protein is considered as a potent mitosis regulator. It induces Aurora B localization and thereby promotes segregation of chromosome.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 3G7, monoclonal
形式 buffered aqueous solution
分子量 antigen ~36.89 kDa
species reactivity human
technique(s) immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型 IgG2bκ
NCBI登记号 NM_032873
UniProt登记号 Q8TF42
运输 dry ice
储存温度 ?20℃
Gene Information human ... UBASH3B(84959)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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