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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-RAF1 antibody produced in mouse

Monoclonal Anti-RAF1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
WH0005894M3
规格纯度
clone 1H4, purified immunoglobulin, buffered aqueous solution
价格
4474.51 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Monoclonal Anti-RAF1 antibody produced in mouse
Anti-v-raf-1 murine leukemia viral oncogene homolog 1
Anti-cRaf
Anti-Raf1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. (provided by RefSeq)

免疫原

RAF1 (AAH18119, 1 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDF

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01092478
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 1H4, monoclonal
形式 buffered aqueous solution
species reactivity human
technique(s) indirect ELISA: suitable
proximity ligation assay: suitable
western blot: 1-5 μg/mL
同位素/亚型 IgG2bκ
GenBank?accession no. BC018119
UniProt登记号 P04049
运输 dry ice
储存温度 ?20℃
Gene Information human ... RAF1(5894)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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