TRPC3 Channel Inhibitor III, Pyr10-Calbiochem

品牌

Sigma-Aldrich

货号

648494

包装型号

10 MG

规格纯度

价格

2313.1 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

TRPC3 Channel Inhibitor III, Pyr10-Calbiochem
N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methylbenzenesulfonamide

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca²⁺entry) and inhibits Carbachol- (Cat. No. 212385) induced Ca²⁺entry in TRPC3-expressing HEK293 cells (IC₅₀= 0.72 ?M; by Fura-2; peak current density pA/pF = -1.01 and -18.50, respectively, with or without 3 ?M Pyr10 by whole cell clamp), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca²⁺release-activated Ca²⁺) channel-mediated SOCE (store-operated Ca²⁺entry) in RBL-2H3 cells (IC₅₀= 13.08 ?M; by Fura-2; pA/pF = -4.39 and -7.50, respectively, with or without 3 ?M Pyr10). A great complement to Pyr2 (Cat. No. 203890), Pyr 3 (Cat. No. 648490), and Pyr6 (Cat. No. 203891) in Ca²⁺signaling studies.
A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca²⁺entry) and inhibits Carbachol- (Cat. No. 212385) induced Ca²⁺entry in TRPC3-expressing HEK293 cells (IC₅₀= 0.72 ?M; by Fura-2), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca²⁺release-activated Ca²⁺) channel-mediated SOCE (store-operated Ca²⁺entry) in RBL-2H3 cells (IC₅₀= 13.08 ?M; by Fura-2). A great complement to Pyr2 (Cat. No. 203890), Pyr 3 (Cat. No. 648490), and Pyr6 (Cat. No. 203891) in Ca²⁺signaling studies.

包装

10 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Reversible: yes
Primary Target
TRPC3

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Schleifer, H. et al. 2012.Br. J. Pharmacol.167,1712.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₈H₁₃F₆N₃O₂S
分子量	449.37

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	semisolid solid
效能	720 nM IC₅₀
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	orange-brown white to off-white
溶解性	DMSO: 100 mg/mL
运输	wet ice
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable