TNF-α Antagonist III, R-7050-CAS 303997-35-5-Calbiochem

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一般描述

A cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC₅₀= 0.631 and 1.45 ?M, respectively) in A549 cells.

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Gururaja, T.L., et al. 2007.Chem. Biol.14,1105.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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