半岛bd体育手机客户端 说明
应用
Protein degrader building block Thalidomide-Photoswitch3-NH2hydrochloride enables the synthesis of PHOtochemically TArgeting Chimeras (PHOTACs), or photoswitchable proteolysis-targeting chimeras (PROTACs) that can be reversibly activated with different wavelengths of light. Developed in the Trauner and Pagano labs, PHOTACs are inactive in the dark but are activated to the cis isomer via irradiation at 390 nm and reversibly deactivated at wavelengths above 450 nm. As described in Reynders et al, this conjugate was used to prepare PHOTAC-I-10 and PHOTAC-II-6 and contains a Cereblon (CRBN)-recruiting ligand, an azobenzene photoswitchable crosslinker, and pendant amine for reactivity with an acid on the target warhead. Light-mediated control of the resulting PHOTAC affords advanced temporal and spatial control of targeted protein degradation.
Suggested wavelengths for photoswitching:
其他说明
PHOTACs enable optical control of protein degradation
PhotoPROTACs: A Novel Biotechnology for Cancer Treatment
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
基本信息
经验(实验)分子式 | C27H22N6O6· xHCl |
分子量 | 526.50 (free base basis) |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥95% |
形式 | solid |
储存温度 | 2-8℃ |
SMILES string | O=C1N(C2C(NC(CC2)=O)=O)C(C3=C1C=CC=C3OCC(NC4=CC=C(/N=N/C5=CC=C(N)C=C5)C=C4)=O)=O.Cl |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |