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位置: 首页> 品牌> Sigma-Aldrich> STAT3 抑制剂 V,Stattic-CAS 19983-44-9-Calbiochem

STAT3 Inhibitor V, Stattic-CAS 19983-44-9-Calbiochem

STAT3 抑制剂 V,Stattic-CAS 19983-44-9-Calbiochem

品牌
Sigma-Aldrich
CAS
19983-44-9
货号
573099
规格纯度
STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.
价格
3543.57 *本价格含增值税费
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半岛bd体育手机客户端 名称:
19983-44-9
STAT3 Inhibitor V, Stattic-CAS 19983-44-9-Calbiochem
6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
STAT3 抑制剂 V,Stattic-CAS 19983-44-9-Calbiochem
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705with little effect towards STAT1 phosphorylation at Tyr701(in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).

包装

25 mg in Plastic Bag(s)
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
STAT3

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.Note:The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.

其他说明

Schust, J., et al. 2006.Chem. Biol.13,1235.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C8H5NO4S
分子量 211.19
MDL编号 MFCD00173799

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 pale yellow
溶解性 DMSO: 10 mg/mL
ethanol: 5 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3

Sigma-Aldrich

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