半岛bd体育手机客户端 说明
一般描述
A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) inSaccharomyces cerevisiaeand acts as an autophagy stimulator both in mammalian culturesin vitroand in aDrosophila melanogasterHD modelin vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.
A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) inSaccharomyces cerevisiaeand acts as an autophagy stimulator both in mammalian culturesin vitroand in aDrosophila melanogasterHD modelin vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.
包装
10 mg in Plastic ampoule
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Tian, Y., et al. 2011.FASEB J.25,1934.Sarkar, S., et al. 2007.Nat. Chem. Biol.3,331.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C11H10BrN3 |
| 分子量 | 264.12 |
| MDL编号 | MFCD02166825 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | pale yellow |
| 溶解性 | ethanol: 10 mg/mL DMSO: 100 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
