SILu^TMProt TIMP1, Metalloproteinase inhibitor 1 human

半岛bd体育手机客户端 说明

一般描述

SILu^?Prot TIMP1 is a recombinant, stable isotope-labeled human TIMP1 which incorporates [¹³C₆,¹⁵N₄]-Arginine and [¹³C₆,¹⁵N₂]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of TIMP1 in mass-spectrometry. SILu^?Prot TIMP1 is a protein of 184 amino acids , with a calculated molecular mass of 20.7 kDa.

生化/生理作用

TIMP-1 is glycoprotein that is over-expressed in the supernatant of tissue extracts of breast, gastric, colorectal, and hepatocellular carcinomas. It belongs to the family of “tissue inhibitors of metalloproteinases,” a group of proteins that help regulate bone turnover. TIMP-1 serum levels are significantly associated with HER2 extracellular domain (ECD)-positivity and poorer disease-free survival among primary breast cancer patients with HER2 overexpression. High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with bortezomib and/or IMiDs during their disease course.

序列

CTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA

外形

Supplied as a lyophilized powder containing phosphate buffered saline.

法律信息

SILu is a trademark of sigma-aldrich Co. LLC

半岛bd体育手机客户端 性质

重组	expressed in HEK 293 cells
质量水平	200
测定	≥98% (SDS-PAGE)
形式	lyophilized powder
效能	≥98% Heavy amino acids incorporation efficiency by MS
适用性	suitable for mass spectrometry (standard)
UniProt登记号	P01033
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable