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位置: 首页> 品牌> Sigma-Aldrich> SILuTMProt CCL2 C-C motif chemokine 2 human

SILuTMProt CCL2 C-C motif chemokine 2 human

品牌
Sigma-Aldrich
货号
MSST0035
规格纯度
SIL MS Protein Standard,13C and15N-labeled
价格
9134.92 *本价格含增值税费
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半岛bd体育手机客户端 名称:
SILu TMProt CCL2 C-C motif chemokine 2 human
Monocyte secretory protein JE
HC11
Monocytechemoattractantprotein1
Monocyte chemotactic protein 1(MCP-1)
Small-inducible cytokine A2
Monocytechemotacticandactivatingfactor(MCAF)
Monocyte chemoattractant protein 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

CCL2, the most thoroughly characterized CC chemokine, is a monocyte-specific chemoattractant that was demonstrated to attract T lymphocytes and NK cells, but not neutrophils. Enhanced expression of CCL2 was demonstrated in a variety of pathologic conditions, associated with inflammation and mononuclear cell infiltration. Extensive experimental evidence suggests that CCL2 is highly expressed in atherosclerotic plaques. In a recent study, CCL2 was shown to have value as a biomarker for risk stratification in both the initial and the chronic phases after an acute coronary syndromes (ACS). In contrast to CRP, CCL2 levels may be an indicator of long-term cardiovascular risk rather than a marker of acute prognosis. In urine, CCL2 levels were directly associated to Systemic Lupus Erythematosus disease activity, making it a non-invasive biomarker (avoiding blood sampling or tissue biopsies).

免疫原

QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKTDYKDDDDKGHHHHHHHHGGQ

生化/生理作用

SILu?Prot CCL2 is a recombinant, stable isotope-labeled human CCL2 which incorporates [13C6,15N4]-Arginine and [13C6,15N2]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of CCL2 in mass-spectrometry. SILu Prot CCL2 is a homodimer consisting of 96 amino acids (including C-terminal polyhistidine and FLAG?tags), with a calculated molecular mass of 11 kDa.

外形

Lyophilized from a solution of phosphate buffered saline.

法律信息

This product is licensed under U.S. Patent No. 7,396,688 and foreign counterparts from E. I. du Pont de Nemours and Company. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product for research and development only, including services for a third party for consideration. The buyer cannot sell or otherwise transfer this product, its components or materials made using this product or its components to a third party. Information about licenses for excluded uses is available from: E. I. du Pont de Nemours and Company; Attn: Associate Director, Commercial Development; DuPont Experimental Station E268; 200 Powdermill Rd.; Wilmington, DE 19803; 1-877-881-9787 (voice), 1-302-695-1437 (fax), licensing@dupont.com.
FLAG is a registered trademark of sigma-aldrich Co. LLC
SILu is a trademark of sigma-aldrich Co. LLC

基本信息

NACRES NA.12

半岛bd体育手机客户端 性质

质量水平 200
生物来源 human
测定 ≥98% (SDS-PAGE)
形式 lyophilized powder
效能 ≥98% Heavy amino acids incorporation efficiency by MS
technique(s) mass spectrometry (MS): suitable
适用性 suitable for mass spectrometry (standard)
UniProt登记号 P13500
储存温度 ?20℃
Gene Information human ... CCL2(6347)

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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