SILu^TMProt B2M beta-2-microglobulin human

半岛bd体育手机客户端 说明

一般描述

SILu^?Prot B2M is a recombinant, stable isotope-labeled human B2M which incorporates [¹³C₆,¹⁵N₄]-Arginine and [¹³C₆,¹⁵N₂]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of B2M in mass-spectrometry. SILu^?Prot B2M is a monomer of 119 amino acids (including C-terminal polyhistidine and flag tags), with a molecular weight of ~14 kDa.
Suggested Quantitative Analysis Parameters
(MRM settings provided for three suggested peptides)

生化/生理作用

B2M is the light chain of the major histocompatibility class (MHC) I molecule expressed on the cell surface of all nucleated cells. Increased urinary B2M excretion has been observed to be an early marker of tubular injury in a number of settings, including nephrotoxicant exposure, cardiac surgery, and renal transplantation, preceding rises in serum creatinine by as many as 4?5 days. B2M may also serve as an early biomarker for AKI (Acute Kidney Injury).

序列

IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMDYKDDDDKGHHHHHHHHGGQ

外形

Supplied as a lyophilized powder containing phosphate buffered saline.

法律信息

SILu is a trademark of sigma-aldrich Co. LLC

基本信息

NACRES

NA.12

半岛bd体育手机客户端 性质

质量水平	200
生物来源	human
重组	expressed in HEK 293 cells
测定	≥98% (SDS-PAGE)
形式	lyophilized powder
效能	≥98% Heavy amino acids incorporation efficiency by MS
technique(s)	mass spectrometry (MS): suitable
适用性	suitable for mass spectrometry (standard)
UniProt登记号	P61769
储存温度	?20℃
Gene Information	human ... B2M(567)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable