SILu^TMLite PTX3 Pentraxin-related protein 3 human

半岛bd体育手机客户端 说明

一般描述

SILu^?Lite PTX3 is a recombinant glycosylated human protein expressed in human 293 cells. It is a homooctamer and a homodecamer consisting of 364 amino acids (monomer)with a calculated molecular weight of 40 kDa. It contains no tags.

生化/生理作用

Pentraxin 3 (PTX3) is a secreted glycosylated protein belonging to the pentraxin superfamily^1.PTX3 is rapidly produced and released by several cell types, in particular by mononuclear phagocytes, dendritic cells (DCs), fibroblasts and endothelial cells in response to primary inflammatory signals (e.g., toll-like receptor [TLR]engagement,TNFα, IL-1?)¹. PTX3 behaves as an acute phase response protein, as the blood levels of PTX3, low in normal conditions (about 25 ng/mL in the mouse, < 2 ng/mL in humans), increase rapidly (peaking at 6–8 h after induction) and dramatically (200–800 ng/mL)during endotoxic shock, sepsis and other inflammatory and infectious conditions, correlating with the severity of the disease. Under these conditions, PTX3 is a rapid marker for primary local activation of innate immunity and inflammation2?6. anti-apoptotic cell survival², cell cycle regulation³, cell adhesion⁴, tissue remodeling⁵and lipid transportation⁶. PTX3 gene expression in human endothelial cells is suppressed to a greater extent by pitavastatin than the expression of 6,000 other human genes that have been examined, suggesting that PTX3 may be a novel biomarker for inflammatory cardiovascular disease⁸.

序列

ENSDDYDLMYVNLDNEIDNGLHPTEDPTPCACGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS

外形

Supplied as a lyophilized powder containing phosphate buffered saline.

法律信息

SILu is a trademark of sigma-aldrich Co. LLC

基本信息

NACRES

NA.12

半岛bd体育手机客户端 性质

质量水平	200
生物来源	human
重组	expressed in HEK 293 cells
测定	≥98% (SDS-PAGE)
形式	lyophilized powder
technique(s)	mass spectrometry (MS): suitable
UniProt登记号	P26022
储存温度	?20℃
Gene Information	human ... PTX3(5806)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable