半岛bd体育手机客户端 说明
一般描述
SILu?Lite CRP is a recombinant human protein expressed in human 293 cells. It is a protein consisting of 226 amino acids (including a C-terminal polyhistidine and FLAG?tags), with a calculated molecular weight of ~25 kDa. SILu?Lite CRP is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.
Suggested Quantitative Analysis Parameters
(MRM settings provided for three suggested peptides)
生化/生理作用
CRP is a hepatically derived pentraxin. It exists mainly as a pentamer in a cyclic structure with 5 identical 23-kD subunits in the blood. In addition to its role as an "acute phase" protein or first-line defense molecule against pathogenic organisms, baseline levels of CRP correlate positively to adverse cardiovascular events. CRP is therefore being considered a “risk factor” for cardiovascular disease. In humans, treatment with statin therapy reduces levels of both LDL-C and CRP, and concurrently there is a reduction in the number of cardiovascular events. A recent study suggests that patients with elevated basal levels of CRP are at an increased risk of diabetes, in addition to cardiovascular disease. A study of over 700 nurses showed that those in the highest quartile of trans fat consumption had blood levels of CRP that were 73% higher than those in the lowest quartile.
序列
QTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWPDYKDDDDKGHHHHHHHHGGQ
外形
Supplied as a solution of phosphate buffered saline with 25% glycerol.
法律信息
FLAG is a registered trademark of sigma-aldrich Co. LLC
SILu is a trademark of sigma-aldrich Co. LLC
基本信息
NACRES | NA.12 |
半岛bd体育手机客户端 性质
质量水平 | 200 |
生物来源 | human |
重组 | expressed in HEK 293 cells |
测定 | ≥98% (SDS-PAGE) |
形式 | liquid |
technique(s) | mass spectrometry (MS): suitable |
适用性 | suitable for mass spectrometry (internal calibrator) |
UniProt登记号 | P02741 |
储存温度 | ?20℃ |
Gene Information | human ... PTX3(5806) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |