Shikonin-CAS 517-89-5-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A naphthoquinone found in the Chinese herbLithospermum erythrorhizon. Possesses significant antibacterial, anti-inflammatory and antitumor activities. Inhibits TNF-α and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αVβ3 and inhibits endothelial cells proliferation and migrationin vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line. Selectively blocks PKM2 (IC₅₀<1 ?M) over PKM1 and PKL activities (IC₅₀in the range of 10-20 ?M), and inhibits cancer cell glycolysis.
A naphthoquinone found in the Chinese herb Shiunko. Possesses significant antibacterial, anti-inflammatory, and antitumor activities. Inhibits TNF-α-induced and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin α_vβ₃and inhibits endothelial cell proliferation and migrationin vitro.Also induces apoptosis in HL60 human promyelocytic leukemia cell line.

包装

10 mg in Plastic ampoule

生化/生理作用

Primary Target
TNF-α-induced and B-16 melanoma-induced angiogenesis
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Chen, J., et al. 2011.Oncogene30,4297.
Li, H., et al. 1999.Phytother. Res.13,236.
Yoon, Y., et al. 1999.Planta Med.65,532.
Hisa, T., et al. 1998.Anticancer Res.18,783.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C16H16O5
分子量	288.30
MDL编号	MFCD00075680

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	red
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3
InChI key	NEZONWMXZKDMKF-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable