半岛bd体育手机客户端 说明
一般描述
A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC50of 25 ?M. Does not inhibit the activation of Rho kinase nor does it affect thein vitroactivities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50= ~5 ?M), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50= ~ 12 ?M in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 ?M.
A cell-permeable, selective, reversible, and ATP-competitive inhibitor of Rho kinase activity (IC50= 25 ?M). Does not inhibit the activation of Rho kinase nor does it affect thein vitroactivities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50~5 ?M), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50~12 ?M in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 ?M.
包装
10 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
ROCK
Target IC50: 25 ?M against ROCK
Product competes with ATP.
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Yarrow, J.C., et al. 2005.Chem. Biol.12,385.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C13H10N2 |
| 分子量 | 194.23 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | yellow |
| 溶解性 | DMSO: 25 mg/mL methanol: soluble |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C13H10N2/c1-2-4-13-11(3-1)12(9-15-13)10-5-7-14-8-6-10/h1-9,15H |
| InChI key | LLJRXVHJOJRCSM-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
Sigma-Aldrich
m.cnreagent.com
