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REV-ERBα Agonist, GSK4112-Calbiochem

品牌
Sigma-Aldrich
货号
554716
规格纯度
The REV-ERBα Agonist, GSK4112 controls the biological activity of REV-ERBα. This small molecule/inhibitor is primarily used for Biochemicals applications.
价格
1526.64 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
REV-ERBα Agonist, GSK4112-Calbiochem
GSK4112
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A selective, cell-permeable ligand (EC50= 250 nM) that acts as a REV-ERBα agonist using a FRET assay. It enhances the recruitment of NCoR peptide to REV-ERBα by up to 70%, and displays no activity towards LRH1, SF1, FXR or ROR, and LXR. Furthermore, it inhibits the promoter activity of Pai1, a known target for REV-ERBα by 30%. This ligand exhibits acute suppression of Bmal1 transcription, and is capable of resetting the molecular rhythm of REV-ERBα-mediated PER2 expression in both Rat-1 lung fibroblasts and on ectopic lung tissues in Luciferase reporter assays. In addition, it is shown to repress the expression of gluconeogenic genes in liver cells and reduce glucose output in primary hepatocytes.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Grant, D., et al. 2010,ACS Chem. Biol.5,925.
Meng, Q., et al. 2008.Journ. Cell. Sci121,3629.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C18H21ClN2O4S
分子量 396.89

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 dark beige
溶解性 DMSO: 50 mg/mL
运输 ambient
储存温度 ?20℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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