Propargyl-PEG₁-acid

半岛bd体育手机客户端 说明

应用

This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains a single PEG unit to help improve solubility.
Propargyl-PEG₁-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₁-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^?molecules) for targeted protein degradation.

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C6H8O3
分子量	128.13
MDL编号	MFCD10689189

半岛bd体育手机客户端 性质

测定	≥95%
形式	liquid
储存温度	?20℃
SMILES string	OC(CCOCC#C)=O
InChI	1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8)
InChI key	GMFDYXLFHSFUHE-UHFFFAOYSA-N

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3