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位置: 首页> 品牌> Sigma-Aldrich> (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na

Pravastatin, Sodium Salt-CAS 81131-70-6-Calbiochem

(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na

品牌
Sigma-Aldrich
CAS
81131-70-6
货号
524403
规格纯度
A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocksin vivocholesterol synthesis (Ki= ~1 nM).
价格
1763.65 *本价格含增值税费
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半岛bd体育手机客户端 名称:
81131-70-6
Pravastatin, Sodium Salt-CAS 81131-70-6-Calbiochem
(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocksin vivocholesterol synthesis (Ki= ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocksin vivocholesterol synthesis (Ki~1 nM). Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.

包装

25 mg in Plastic Bag(s)
Packaged under inert gas

生化/生理作用

Primary Target
AMG-CoA reductase
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target Ki: ~1 nM inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blockingin vivocholesterol synthesis

警告

Toxicity: Environmental Hazard (N)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kwak, B., et al. 2000.Natl. Med.6,1399.
Hamelin, B.A., and Turgeon, J., 1998.Trends Pharmacol. Sci.19,26.
Narisawa, T., et al. 1996.Jpn. J. Cancer Res.87,798.
Cohen, L.H., et al. 1993.Biochem. Pharmacol.45,2203.
Koga, T., et al. 1990.Biochim. Biophys. Acta.1045,115.
Yoshino, G., et al. 1986.Diabetes Res. Clin. Pract.2,179
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 crystalline solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性 water: 100 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
InChI key VWBQYTRBTXKKOG-IYNICTALSA-M

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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