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位置: 首页> 品牌> Sigma-Aldrich> Pomalidomide-piperazine-C1-4-piperidine hydrochloride

Pomalidomide-piperazine-C1-4-piperidine hydrochloride

品牌
Sigma-Aldrich
货号
923877
包装型号
规格纯度
价格
2814.84 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Pomalidomide-piperazine-C 1-4-piperidine hydrochloride
2-(2,6-Dioxopiperidin-3-yl)-4-(4-(piperidin-4-ylmethyl)piperazin-1-yl)isoindoline-1,3-dione hydrochloride
Protein degrader building block
Crosslinker-E3 Ligase ligand conjugate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Protein degrader building block Pomalidomide-piperazine-C1-4-piperidine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC?(proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

其他说明

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation:from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式 C23H29N5O4· xHCl
分子量 439.51 (free base basis)

半岛bd体育手机客户端 性质

质量水平 100
储存温度 2-8℃
SMILES string O=C1C(N2C(C(C=CC=C3N4CCN(CC5CCNCC5)CC4)=C3C2=O)=O)CCC(N1)=O.Cl

安全信息

象形图 GHS08
警示用语: Danger
危险声明 H360D
预防措施声明 P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类 Repr. 1B
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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